Products we work with and recommend
Sodium Phenyl Butyrate
Butyrate is one of three fats made in the colon (acetate, n‐butyrate, propionate). Recently, investigators demonstrated that sodium phenyl butyrate and taurursodiol (bile acid) slowed ALS disease progression over six months, with impacts on various activities of daily living such as a patient's ability to walk, talk, use utensils or swallow food. Although studies have been done using oral butyrate, at BodyScience, we have found that the intravenous use of Sodium Phenyl butyrate is more effective. As ALS is a fast-progressing disease our patients need an alternative route to use at home that is more beneficial than oral administration. We recommend the use of rectal suppositories. The rectal mucosa has extensive blood and lymph supply that is capable of a more effective and faster systemic absorption and higher bio-availability. This route of administration allows a greater amount of effective drug into the bloodstream, as it has not been influenced by upper gastrointestinal tract digestive processes. Rectal administration also reduces side-effects such as gastric irritation, nausea, or vomiting. Also administering butyrate per rectum, close to the colon is more effective since this is the location where butyrate is normally manufactured.
Chaperone 1: is composed of bile salts, SOD, and catalase. This is used to improve the ability of butyrate to move into the cells as it can function as a heat shock protein. SOD binds to molecules of copper and zinc to break down toxins. Charged oxygen molecules called superoxide radicals are byproducts of normal cell processes, these free radicals must be broken down regularly to avoid damaging cells, in this case motor neurons.
Digestive enzymes 1 and 2: having proper digestive health is critical in reducing gastrointestinal inflammation. We have evaluated the gastrointestinal health of a small cohort of patients with motor neuron disorders. A majority of patients had signs of intestinal inflammation and showed elevated or borderline elevated inflammatory biomarkers in their stool analyses (fecal secretory IgA, calprotectin, and/or eosinophilic protein X). In retrospect, all patients had GI symptoms that predated the onset of neurological symptoms.
Detox Shake: effective as a metabolic clearing agent, while also supporting hepatic function, energy production, and intestinal balance. This formula includes easily digested, certified organic, pea protein, medium-chain triglycerides, fiber, and an extensive array of antioxidants.
This powerful combination supports safe and effective detoxification. Mounting evidence suggests that liver dysfunction commonly occurs in ALS. Research has shown a range of liver abnormalities in ALS patients including the disturbance of unconjugated bilirubin metabolism, mitochondrial defects, and copper accumulation in hepatic lysosomes. More recently, clinical studies suggest that hepatic steatosis (fatty liver degeneration) is a common and unique phenomenon in motor neuron diseases including ALS, being found in 76% of ALS patients.
We have been working with BIOMEIQ products for a really long time and these four products are amazing for maintaining healthy muscle.
You will be receiving a six-month supply of medication due to the following observations:
Studies looking at butyrate in people with ALS have been done over a 24-week period, showing benefit throughout the clinical trial. Patients who completed the trial were eligible to participate in an open-label extension, in which all patients received the medication aiming to assess the long-term safety and efficacy of the medication. In three-year survival analysis, it was found that participants originally randomized to receive the medication had a significant increase in survivability compared to those who were originally randomized to receive placebo.
How to get the products?
To get the products please schedule an appointment with our clinic (videoconference), our team of experts will explain the products and benefits.